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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
25.76
Human Site:
T220
Identified Species:
56.67
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
T220
L
S
F
N
L
I
Q
T
E
R
Q
N
H
A
R
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
T220
L
S
F
N
L
I
Q
T
E
R
Q
N
H
A
R
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
T219
L
S
F
N
L
I
Q
T
E
R
Q
N
H
A
R
Dog
Lupus familis
XP_541516
663
70246
T225
L
S
F
N
L
I
Q
T
E
R
Q
N
H
A
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
T185
L
S
F
N
L
I
Q
T
E
R
Q
N
H
A
R
Rat
Rattus norvegicus
Q91V26
383
42400
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
K125
V
A
Q
S
W
A
K
K
I
W
E
M
A
E
E
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
D38
W
L
Y
G
N
H
C
D
S
V
L
R
R
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
T254
V
P
Y
D
L
Y
V
T
K
H
S
N
F
A
I
Honey Bee
Apis mellifera
XP_394823
620
69588
T210
R
P
Y
E
V
H
V
T
K
C
P
N
Y
A
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
T287
I
K
M
E
V
V
K
T
T
K
A
G
H
A
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
N.A.
N.A.
0
0
N.A.
26.6
26.6
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
0
N.A.
N.A.
N.A.
33.3
6.6
N.A.
53.3
53.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
0
0
0
10
0
0
0
0
10
0
10
73
10
% A
% Cys:
0
0
0
0
0
0
10
0
0
10
0
0
0
0
0
% C
% Asp:
0
0
0
10
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
19
0
0
0
0
46
0
10
0
0
19
10
% E
% Phe:
0
0
46
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
10
0
0
0
0
0
0
0
10
0
0
0
% G
% His:
0
0
0
0
0
19
0
0
0
10
0
0
55
0
0
% H
% Ile:
10
0
0
0
0
46
0
0
10
0
0
0
0
0
10
% I
% Lys:
0
10
0
0
0
0
19
10
19
10
0
0
0
0
0
% K
% Leu:
46
10
0
0
55
0
0
0
0
0
10
0
0
0
0
% L
% Met:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
0
0
46
10
0
0
0
0
0
0
64
0
0
0
% N
% Pro:
0
19
0
0
0
0
0
0
0
0
10
0
0
0
0
% P
% Gln:
0
0
10
0
0
0
46
0
0
0
46
0
0
0
0
% Q
% Arg:
10
0
0
0
0
0
0
0
0
46
0
10
10
0
64
% R
% Ser:
0
46
0
10
0
0
0
0
10
0
10
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
73
10
0
0
0
0
0
0
% T
% Val:
19
0
0
0
19
10
19
0
0
10
0
0
0
0
0
% V
% Trp:
10
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
28
0
0
10
0
0
0
0
0
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _